CHANGES IN INTESTINAL PERMEABILITY DEMONSTRATED BY LOW MOLECULAR WEIGHT POLYETHYLENE GLYCOL (PEG) POLYMERS
نویسندگان
چکیده
منابع مشابه
Immunogenicity of Polyethylene Glycol (PEG)
Covalent attachment of polyethylene glycol (PEG) to active proteins (PEGylation technology) successfully generated several FDA-approved compounds, including four blockbusters, which are considered non immunogenic. However, PEG antibodies and intolerance to the infusion were reported in some patients with gout treated with pegloticase, a PEG-uricase recently approved by the FDA (Food and Drug Ad...
متن کاملElimination of low molecular weight polyethylene glycol 400 in the urine following an oral load, as a measure of intestinal permeability.
After an oral load of 10 g polyethylene glycol, its concentration in the urine was measured by gas chromatography. The coefficient of variation of the imprecision between run was about 11%. The urinary excretion was 25% of the administered dose with a coefficient of variation of the interindividual variation 26% and the intraindividual variation between 13% and 29%.
متن کاملLow Volume Polyethylene Glycol (PEG) Plus Ascorbic Acid, a Valid Alternative to Standard PEG
Adequate bowel preparation is essential to improve colonoscopy quality. Inadequate bowel preparation may result in lower colonoscopy completion rate, longer duration of colonoscopy, and lower diagnostic yield for polyps. Polyethylene glycol (PEG) has been shown to be safe and effective, and thus regarded as the gold standard for bowel preparation before colonoscopy. However, the standard PEG re...
متن کاملLow molecular weight polyethylene glycol induces chromosome aberrations in Chinese hamster cells cultured in vitro.
The human population is widely exposed to polyethylene glycol (PEG) and its chemical derivatives, which are widely used as vehicles or co-solvents in many pharmaceutical and cosmetic preparations. However, PEG polymers of low molecular weight differ significantly from polymers of higher molecular weight in their physico-chemical properties, biological effects on cell permeability and their abso...
متن کاملSensitivity of PEGylated interferon detection by anti-polyethylene glycol (PEG) antibodies depends on PEG length.
Attachment of poly(ethylene glycol) to proteins can mask immune epitopes to increase serum half-life, reduce immunogenicity, and enhance in vivo biological efficacy. However, PEGylation mediated epitope-masking may also limit sensitivity and accuracy of traditional ELISA. We previously described an anti-PEG-based sandwich ELISA for universal assay of PEGylated molecules. Here, we compared the q...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Pediatric Research
سال: 1987
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-198709000-00051